The Monkey and the Dolphin. Simultaneously bringing you feelings of awesomeness and huh?
Illustrated by Gustave Doré (1867). Via Fresh Photons.
Illustrated by Gustave Doré (1867). Via Fresh Photons.
Otherwise known as the “just finish your f***ing work” contraption. Version two includes a glass of Scotch.
Patented by Isidor Keller in 1884. Via Futility Closet
What if there was a non-political research project that involved a collaboration between NASA scientists and Environment Canada scientists? How easy would it be for a journalist to talk to the scientists involved?
It turns out it would take only 15 minutes for something to be arranged with NASA. With Environment Canada, however, it would take the activities of 11 media relations people, sending over 50 pages of internal emails, before a list of irrelevant information was finally sent back – all of this long after the deadline had passed. This is what happened to journalist Tom Spears in April 2012.
With this, this Terry Podcast episode asks a simple question: If it was this difficult to get interviews for a positive science story, what would happen if a journalist needed to actually ask some tough questions? Please take a listen as this episode of the Terry Podcast examines the relationship between media and Canadian Government scientists, and questions whether the Harper government has politicized science.
Please listen and share:
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CiTR 101.9FM: Every Other Wednesday, 1PM |
T-shirt now available in honour of my lab’s Molecular Biology 5 day professional workshop (next one held in Vancouver from Feb 17th to 21st, 2014 – more details here). Note that all revenues go towards my lab’s outreach programming, which can be surveyed here.
Anyway, if you’re a scientist in need of a quick refresher in these techniques, or someone in a parallel field and want to learn more about the various methodologies that keep infiltrating your research discipline, then take a peek and consider signing up (or pass along to a colleague).
Also, if you’ve got a friendly neighbourhood bulletin board nearby, it would be AWESOME if you could put this poster (pdf) up somewhere.
T-shirt available for purchase here.
Via my lab’s website (bioteach.ubc.ca)
MOLECULAR BIOLOGY TECHNIQUES WORKSHOPS (SPRING 2014 PROGRAM):
To inquire about registration, please contact Dr. David Ng at db@mail.ubc.ca
(1) ONE WEEK VERSION
Dates: February 17th to 21st, 2014 (5 days: Monday to Friday)
Price: CAN$1400 (does not include room or board)
Reviews and testimonies from our last workshop (June 2013)
“Excellent workshop! Very good review of the molecular biology techniques. Dave makes the theory very clear and interesting. Also takes time to answer specific questions/issues regarding personal ongoing projects. The workshop will definitely help for future troubleshooting. Thanks!”
Chantale André, Environment Canada
“Fabulous teacher, well organized, gives a good introduction into the field. I enjoyed it! Thanks!”
Michael Fischer, Department of Chemistry, University of British Columbia.
“I found it to be a nice combination of review and new material. It was well paced, with each day balanced with lecture and hands-on work. Dave does a great job with getting the information across in an easy to understand manner, and was energetic and entertaining to boot.”
Jeremy Johnson, Okanagan Specialty Fruits
“Excellent workshop. Got lots of information. Activities were great. After this workshop, I got a direction for my acquisition of knowledge to proceed in my area of specialization. This workshop has benefited me extremely.”
Poonam Singh, School of Horticulture, Kwantlen Polytechnic University
More testimonials can be found here.
INSTRUCTOR: Dr. David Ng
DESCRIPTION: This intense 5 day workshop will focus on a myriad of different techniques used in the molecular manipulation of DNA (general cloning, transformation, silica kits, pI kits, PCR, qPCR), RNA (isolation, reverse transcription) and protein (SDS-PAGE, 2D gels), as well as lectures that will describe some high throughput technologies such as SNP analysis, and next generation sequencing. Primarily aimed at researchers who are new to the area, familiar but require a quick updating, or would like more practical bench training.
PHILOSOPHY: Whilst molecular techniques have evolved at a blindingly fast rate over the last few decades, the underlying biochemical principles behind the vast majority of them have actually changed little. This workshop therefore combines opportunities to perform the latest, as well as commonly used older techniques, with particular attention to the chemical nuts and bolts behind them. In all, this allows the researcher to not only gain needed familiarity with the techniques, but also achieve a comfortable theoretical level to allow for both (1) that all important skill of troubleshooting, and (2) the often undervalued skill of judging the utility of “tricks” that aim to speed up, or lower costs of a given methodology.
NOTE: You can also see our June 2013 editions of our lecture notes, and lab manuallab manual for a frame of reference.
LOCATION:
Located in the heart of the UBC campus, the Michael Smith Laboratories is a testament to the vision of its founding Director, Dr. Michael Smith. Under his leadership, a gifted team of young scientists were recruited. These scientists have gone on to develop internationally renowned programs of research and training. The second and third floors of the new building are dedicated to the research facilities of the former Biotechnology Laboratory. The Stewart and Marilyn Blusson Education Forum is located on the ground floor and is open to the public. The molecular techniques workshops are held in the teaching lab, room 105 of this forum.
(click here for detailed directions)
REGISTRATION DETAILS:
Registration is essentially through first: an email inquiry for space (contact Dr. David Ng at db@mail.ubc.ca), second: a verbal commitment and then third via payment. Your place is essentially secured with payment, which more or less equates to a first come first serve mechanism. This payment would be a CAN$1400 cheque (or equivalent) payable to “The University of British Columbia” and sent to
Dr. David Ng
Michael Smith Laboratories
301-2185 East Mall,
University of British Columbia
Vancouver, BC, CANADA V6T 1Z3
If you prefer us to send an invoice, please let us know and we can arrange that accordingly. Note that we can accommodate a maximum of 16 clients, but on occasion up to half of these spaces are already reserved for predetermined group clients. Therefore, it’s best to put your name down as soon as possible if you are interested in the workshop.
REFUND POLICY
Your spot in the workshop is secured when we receive your payment. The deadline for receipt of payments is 2 weeks prior to the workshop start date. Unfortunately, we are unable to issue any refunds after this deadline has passed.
DAY TO DAY SCHEDULING DETAILS:
Workshop will begin each day at 9am sharp and usually end between 4pm and 5:30pm. A detailed final schedule and syllabus will be released to clients as the date draws nearer.
MATERIALS:
All paper materials will be provided on the first day of the workshop. Downloadable versions will be available about 3 weeks before the workshop begins. Whilst we do not require the clients to “study” these documents, we do ask that clients take a moment to peruse the first day practical materials. All safety gear (including lab coats) is provided at the workshop.
ACCOMMODATIONS:
Here are some accommodation options that are basically on campus. Costs involved would vary (I think the most budget option would be the Vancouver Youth Hostel which is about a 15minute bus ride away). The closest would be those of Gage through UBC conferences. The others (except for point grey house) are all a relatively short walk away.
International Youth Hostel at Jericho Beach
UBC accomodations (on campus – note there are only 47 available)
St. John’s College (on campus)
Green College (on campus)
St. Andrew’s Hall (summer only)
Point Grey House (off campus, but only 10 minute bus ride away)
Alternatively, Downtown Vancouver offers a variety of accommodation options, but would entail about a 30-40minute bus ride each way. Depends on your preference since the Campus is pretty quiet at night time, whereas other areas would be more interesting. Go to www.expedia.ca, and select:
hotel > near an attraction/vancouver > type in “University of British Columbia”
Usually the out of town clients make use of a little extra time after or before the workshop in visiting some of the sights Vancouver has to offer. I often strongly recommend this since the city and surrounding locale are really quite spectacular. In particular Whistler-Blackcomb is a world famous ski/outdoor resort, and is only a 2 hour drive away. Ski season usually opens in mid November (click here for more info)
By DAVID NG and BENJAMIN R. COHEN
Click on the image for larger graphic.
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(CLICK HERE FOR PIN-UP POSTER – pdf file ~1Mb)
– We suggest photocopying at 129% – LTR to 11×17 –
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ABSTRACT
The “Candy Hierarchy” represents a thoroughly authoritative attempt to scientifically measure and classify Halloween Candy by assessing “joy induction.” More or less. Since 2006, Cohen and Ng have curated these rankings as an ongoing longitudinal study, one which reassesses itself through the use of the newest technologies (often teeth and jaws) and robust scientific peer review (comments). This article therefore presents the latest rankings with insight into the complex cultural underpinnings of “sweet” things. Specific notes of interest are two fold: (1) the emergence of a child-centric sucro-fructo-tastic gummi/chewy/taffi layer into the upper strata and (2) the recent prominence of corporatized corn fructose agents potentially, but we doubt it, influencing the hierarchy. Speaking of corporate influence, we are proud to be sponsored by Sweetum’s this year. Sweetums!: When fructose jitters can’t wait, try Sweetums, an American delight! In conclusion, these findings continue to demonstrate the enormous challenge in monitoring the constantly changing landscape of candy joy induction. Except, of course, for Whoppers – Whoppers still blow. And, good god, if I get one more box of Nerds. They’re gone. It’s done. Boom. Drop the mic.
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DISCUSSION
This year, we had money. Gobs of money. Like lots and lots. If Everlasting Gobstoppers were money and not gobs used to stop things, we would be that. So much money it was crazy town for a while. It’s like, this year for Halloween we’re not going to be giving out Toblerone; we’re going to be giving out 3D printers that make Toblerone. But don’t let’s get all braggy. Our point is this: we got big cash and we did fancy research.
And what did this research look like? Well, all sorts of scientific things—things like booking time at CERN to collide candy corn and chocolate bars together in an attempt to explain why some fundamental particles (bodies) have (more) mass; things like using next gen sequencing methodologies to elucidate the genetic variation within populations of same-flavored and different-flavored Starbursts; things like setting up a Dancing-with-the-Stars-like competition where we had animated FTIR machines (which we printed with our disposable 3D printers) spit out competing glucose fingerprint codes to see which danced the best. Was most of this wasted time, effort, and money? Sure, maybe…the CERN data showed that colliding candy together at high speeds resulted in smaller bits of candy (intriguing); the Starburst genome project essentially suggested that Starbursts don’t, in fact, have genomes (curious); and it’s not clear that Dancing FTIR thing even made sense. But it’s not for us to decide the findings’ value. That’s what the peer community is for. Who knows how this knowledge might one day be applied? Besides, the stuffed coats at Sweetum’s tell us we can’t actually make the good data public until Sal in marketing vets it. I think this discussion is supposed to be redacted, actually. Rob, can you go check on that before this runs?
Regardless, we can state this: lo and behold, this year’s hierarchy reveals a bi-modal fracturing at the top strata. Previous rankings had found chocolate dominance at the top. The new hierarchy reflects discoveries made in the last year whereby some kids don’t think chocolate is top tier. Seemed like bullshit at first—because, really? Non-chocolate? But data don’t lie. So check out the graphic above.
Know what else? After years of failed get-it-right fast schemes, in this scheme we got it right. And fast. With some methodological retooling, more data sets, further research, and hundreds of additional peer review comments, the hierarchy is now entirely correct. There will be no need for comments. You can turn the internet off now. Yes yes, we said that last year, and the numerous years before. But that was before Twitter was big so nobody really read this. People always say they’re super confident, and you can never believe them, and don’t ever trust who ever acts like they’re one hundred percent certain. It’s just, if someone says something is entirely correct, you have to be a bit skeptical, right? But this time we are one hundred percent confident; this hierarchy is entirely correct. Why? Because of that corporate sponsorship. That’s why we’re proud to thank Sweetum’s Good Times High Fructosery for funding this year’s hierarchy. Sweetum’s, the quicker picker upper. Anyway, the scientific process is largely structured by corporate mechanisms and economic considerations, we’re told. Scientific research is underwritten by commitments to those problems our funders deem worthy of study. Right? And so here we are. Lots of sugar. Eventual diabetes. Meager dentistry. Yum.
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SOME PEER REVIEW COLLECTED HERE
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FOOTNOTES
1. Because like, score! (Bcsizemo, 2010)
2. a.k.a. God’s Candy
3. These may be rolled to a friend.
4. Not sure if this should be included. Systematics are still on going – denomination appears to be key.
5. Like that fish you’ve seen on television. You know – the one which looks like it can breathe air and stuff.
6. Appropriate ranking may depend entirely on date of purchase versus date of opening. Experts in this field often refer to this dichotomy as “fresh CCE” versus “stale CCE,” or FCCE versus SCCE (Beschizza, 2011). Note that its interior has also been described as “pustulent.” (Petersen, 2010)
7. Sometimes spousal influence forces these placements as with, ahem, this primarily southern delicacy.
8. Blame the children on this one, Canadian children too. Also, sponsored by Sweetums (“Sweetums!: When fructose jitters can’t wait, try Sweetums, an American delight!”) whose corporate dollars may or may not be messing with your heads.
9. Always a contentious subject with a rich history of controversy. Briefly: Candy Corn, as of 2006, remained unclassified, but as of 2007 had been tentatively placed in the Upper Chewy/Upper Devonian. 2008: no sighting. This year, we have elected to place in a new tier, although what this means exactly has yet to be determined.
10. Includes comparable Commonwealth version of “Smarties.” (Devo, Legionabstract, gadgetgirl et al, 2011)
11. Although has also been classified as packing material (Cunning, 2010)
12. Placed solely to acknowledge, make fun of, and possibly undermine British opinions. Google it, but be careful when you google it (2012).
13. This is from EU pressure, known in diplomatic circles as the “Hornby Concession” (see his many footnotes from the 2012 version).
14. In which we acknowledge the complex underpinnings of this here Candy ranking exercise: apparently, the wrapper of the Ferrero Roche gets a higher ranking than the candy itself (due to high artwork potential). (Son of Anthrodiva 2012)
15. Whoppers blow.
16. The authors are curious as to which neighborhoods you belong to.
17. Also a hot mess of debate. Not to be confused with hot messes involving actual persons named “Mary Jane.” (Girard, franko, lexicat, Easton, Petersen, Halloween_Jack, 2012)
18. The discontinued candy, not the equally rankable discontinued board game.
19. Oh smack, can you even imagine if you got Fritos?
20. You know, we don’t even know what this is, but, hell, your sister marries an Australian, they have a kid, now you’ve got a niece, and you want a nice life for her, you want her to have a stake in the hierarchy, so okay, Aussie Lollies — Picnic bars, cherry ripe, Frys Turkish delight, probably something Chazzwozzer-based too, knock yourself out.
21. In a word, surreal… Plus grandpas with eyepatches always make everything better. Pretty sure, this is reproducible. (Gyrofrog, petertrepan, Koerth-Baker, Olsen 2012)
22. By some accounts, these two are actually one and the same (Gadgetgirl, 2010)
23. Yet some would be just as well to be left off. Bit-o-Honey, for example, might be called a lower tier member, but why bother? It says to your trick-or-treaters, “Here, I don’t care, just take this.” The lesson of Bit-o-Honey is: you lose. Doorstep offers of lectures in civics, too. You’re making a social statement–“I hate you and everything you represent”– when you give these out.
24. Yes, we really meant fruit that is healthy, clean-cut upstanding fruit that takes time from its gym membership and all the demands that come with it to contribute a positive message of citizenship and camaraderie to the community. This isn’t a typo of healthy for healthful. (see U.M.H. 2011)
25. Research has further defined this relationship. Currently, it has been suggested that Blackwing Pencils > Hugs > Creepy Hugs > Pencils. (Lobster, Prufrock451, and Warreno, 2010)
26. Unless it’s something caramel, pronounced “caramel.”
27. Unless you eat them properly. To quote Anonymous, 2010: “The trick to realizing how brilliant and delicious Now ‘n Laters are is a two step process. The first step is to carefully read the name of the candy. “Now ‘n Later.” What does it mean, you ask? Well, it implies that the candy will be different “now” (when you put it in your mouth) and at some point “later” in time. A small leap of logic takes us to the second step: be patient. You need to suck on it for a while until it softens. If you skip this step, the Now ‘n Later will be an inedible, rock-like colorful brick quite worthy of the low end of the hierarchy. But if you are patient in your candy-eating process, oh the rewards you will reap!”
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Originally published at Boingboing.net.
Found at Futility Closet and noted here for tagged archive.
In February 1962 John Glenn circled Earth three times on Friendship 7.
When he landed, he received a card from the International Flat Earth Research Society.
It said, “OK wise guy.”
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PLOS BIOLOGY (March 2013). Vol 11 Issue 3. e1001501 p1-6
Click on the image to go to full text paper. Click here for pdf download.
ABSTRACT
Electrocytes contain membrane proteins that allow the polarization of the plasma membrane, thereby allowing the generation of electricity in animals. It has been long established how electricity is generated in the electric eel, but recent studies found similar electrocytes to be active in electric mice. We aimed to study the basis behind electric discharge in a land animal. We found that the voltage-gated sodium channel, Nav1.4a, was expressed in electric organs of the electric mouse, Pokemon pikachu and the electric eel, Electrophorus electricus. However, Nav1.4a was not expressed in the muscle cells of E. electricus while it was expressed in the muscle cells of P. pikachu and other rodents. We also found that P. pikachu and E. electricus shared similar amino acid substitutions at the nonconserved region of this protein. Voltage-clamp technique gave insight on the much greater potential differences generated by P. pikachu compared to electric eel and finally, microscopy analysis revealed greater Nav1.4a numbers in P. pikachu, potentially correlating with aforementioned greater electric potential generation, which perhaps lead to its capability to discharge electricity readily through air.
AUTHOR SUMMARY
Many species of fish are able to generate weak or strong electric discharges, either for communication or for stunning predator or prey. The electric organ, made of electrocytes, is responsible for generating electric discharge. Electrocytes are thought to be derived from neuronal and muscle cells. The voltage-gated sodium channel, Nav1.4a, is found to be absent in the muscle cells, but is highly expressed in the electric organs of electric fishes. In our study, we looked at Nav1.4a in a species of mouse, P. pikachu, that also generates electricity, but through air instead of water. We compared this electric mouse with electric eel as well as nonelectric rodents. Here, we found that Nav1.4a is expressed in both the muscles and electric organs of P. pikachu. In terms of the amino acid sequence, the channel protein of P. pikachu was more similar to the electric eel rather than the rodents. We then observed that P. pikachu possessed much greater numbers of Nav1.4a and generated a much higher potential compared to the electric eel, which may explain its ability to discharge electricity through air.
Via the Science Creative Quarterly (with apologies to PLOS Biology)
Damn, these are pretty…
Outstanding work by Simon C Page (a.k.a Rare Minimum), and available as cards for purchase. Via Fresh Photons.
Almost peed my pants when I read this. Plus I love it, because it’s a perfect commentary on the diverse nature of science culture (i.e. we can be silly and crude as well as science-y). Would be wonderful if, one day, Ms. Beaton decides to do a book on science history – heck, I would even love to commission that sort of project (ooh ooh – maybe a “famous folks in science history” phylo deck?)
By Kate Beaton.
These are the sorts of images that would be perfect to segue into discussions around the environment and media spin.
By Laura Plageman, via Sweet Station.